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Esomeprazole, sold under the brand name Nexium [or Neksium] among others, [2] is a medication which reduces stomach acid. [11] It is used to treat gastroesophageal reflux disease , peptic ulcer disease , and Zollinger–Ellison syndrome .
Esomeprazole is the (S)-(−)-enantiomer of omeprazole and provides higher bioavailability and improved efficacy, in terms of stomach acid control, over the (R)-(+)-enantiomer of omeprazole. In theory, by using pure esomeprazole the effects on the proton pump will be equal in all patients, eliminating the "poor metabolizer effect" of the ...
Naproxen/esomeprazole, sold under the brand name Vimovo, is a pain reliever medication in the form of a tablet for oral consumption, containing naproxen, a nonsteroidal anti-inflammatory drug (NSAID), and a delayed release formulation of esomeprazole, a stomach acid–reducing proton-pump inhibitor (PPI). [2] [3] It is produced by AstraZeneca. [4]
AstraZeneca also developed esomeprazole (Nexium) which is a eutomer, purely the (S)-enantiomer, rather than a racemate like omeprazole. [medical citation needed] Omeprazole undergoes a chiral shift in vivo which converts the inactive (R)-enantiomer to the active (S)-enantiomer, doubling the concentration of the active form. [59]
Esomeprazole (OTC and Rx-only in the US and Australia) [86] Ilaprazole (not FDA-approved as of July 2019) Lansoprazole (OTC and Rx-only in the US) [85] Omeprazole (over-the-counter drug) [86] Pantoprazole [87] Rabeprazole [88] There is no clear evidence that one proton pump inhibitor works better than another. [1] [89]
As of 2006, a standard triple therapy is amoxicillin, clarithromycin, and a proton pump inhibitor such as omeprazole, [15] lansoprazole, pantoprazole, or esomeprazole. Protocols with metronidazole were also in use. [15] An example of a fixed-dose combination is PantoPac, containing pantoprazole, clarithromycin, and amoxicillin. [citation needed]
Esomeprazole; Omeprazole This page was last edited on 6 May 2021, at 01:32 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 ...
Esomeprazole, a blockbuster drug, is an enantiopure drug containing a sulfoxide functional group. The related drug omeprazole is the racemic version. DMSO is a widely used solvent. The sulfoxide functional group occurs in several drugs. Notable is esomeprazole, the optically pure form of the proton-pump inhibitor omeprazole.
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