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Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. [18] In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. [ 19 ]
Effects on heart related health problems or death is unclear. [3] Common side effects include tingling, dizziness, trouble sleeping, and constipation. [3] Serious side effects may include suicide, abuse. [3] Use is not recommended during pregnancy. [1] Phentermine is a stimulant and appetite suppressant. [3]
The FDA requested that the manufacturers of fenfluramine and dexfenfluramine stress the potential risk to the heart in the drugs' labeling and in package inserts. [11] The FDA continued to receive reports in 1997 of valvular heart disease in people who had taken these drugs. This disease typically involves the aortic and mitral valves.
From 1980 to 1985, Dr. Jay Cohn of the University of Minnesota led a clinical trial in collaboration with the US Veterans Administration called the Vasodilator-Heart Failure Trial (V-HeFT I) that tested whether the combination of isosorbide dinitrate and hydralazine increased survival in patients with heart failure.
In the United States, the 800 mcg tablet was 6.75 times more expensive as of 2020 than the lozenge. [ 207 ] [ 208 ] As of 2023, the average cost for an injectable fentanyl solution (50 mcg/mL) is around US $17 for a supply of 20 milliliters, depending on the pharmacy. [ 209 ]
Adderall and Mydayis [11] are trade names [note 2] for a combination drug containing four salts of amphetamine.The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. [13]
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