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Holoprosencephaly, the failure of the embryonic prosencephalon to divide to form cerebral hemispheres, occurs with a frequency of about 1 in 8,000 live births and about 1 in 200 spontaneous abortions in humans and is commonly linked to mutations in genes involved in the hedgehog pathway, including SHH and PTCH. [37]
Key members of the architecture and microarchitecture team included Geoffrey Brown (HPL co-lead), Giuseppe Desoli (HP), Gary Vondran (HP), Trefor Southwell (ST), Tony Jarvis (ST), and Alex Starr (ST). The architecture was really a true cross company development, co-sited for the early duration of the project, lasting some two years.
Multiple such glycoproteins have been characterized: Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). [16] Among these, Shh is the most potent. It binds and inactivates the transmembrane protein Patched1 (PTCH1). In the absence of Shh, PTCH1 inhibits the activity of Smoothened (SMO), another transmembrane protein.
The follow-on research effort, LAPCAT II began in 2008 and was to last four years. [72] STRATOFLY MR3 is an EU research program (German Aerospace Center, ONERA and universities) with the goal of developing a cryogenic fuel 300-passenger airliner capable to fly at about 10,000 km/h (Mach 8) above 30 km of altitude. [73] [74]
The Miles M.52 was a turbojet-powered supersonic research aircraft project designed in the United Kingdom in the mid-1940s. In October 1943, Miles Aircraft was issued with a contract to produce the aircraft in accordance with Air Ministry Specification E.24/43.
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Sonic and ultrasonic weapons (USW) are weapons of various types that use sound to injure or incapacitate an opponent. Some sonic weapons make a focused beam of sound or of ultrasound; others produce an area field of sound. As of 2023 military and police forces make some limited use of sonic weapons.
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