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  2. Prazosin - Wikipedia

    en.wikipedia.org/wiki/Prazosin

    Prazosin is active after taken by mouth and has a minimal effect on cardiac function due to its α 1-adrenergic receptor selectivity.When prazosin is started, however, heart rate and contractility can increase in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure.

  3. List of drugs known for off-label use - Wikipedia

    en.wikipedia.org/wiki/List_of_drugs_known_for...

    Prazosin (Minipress) for nightmares: prazosin is approved for the use of hypertension. A 2012 systematic review showed a small benefit for the treatment of PTSD-associated night terrors. Other non-FDA-approved uses for prazosin include the treatment of Raynaud's disease and poisoning due to scorpion venom.

  4. Alpha-1 blocker - Wikipedia

    en.wikipedia.org/wiki/Alpha-1_blocker

    The risk of first dose phenomenon may be reduced or eliminated by gradual-dose titration, since the adverse effects of Prazosin are dose-related. [7] This is also the case for Tamsulosin and it may be assumed that the others alpha-1 blockers work in a similar manner, since Tamsulosin is an alpha-1-a blocker and Prazosin is an alpha-1 blocker ...

  5. First-dose phenomenon - Wikipedia

    en.wikipedia.org/wiki/First-dose_phenomenon

    This may occur with the class's better known side effect of dry cough (due to decreased breakdown of bradykinin), though there is no clear relationship between the two side effects. The first dose phenomenon in ACEi is reduced and made safer by avoiding diuretics for 24 hours prior to first dose, taking first dose at night (so avoiding falls ...

  6. 50 Real-Life Insurance Horror Stories That Might Leave You ...

    www.aol.com/americans-share-55-insurance-horror...

    Doctors kept trying to switch pain meds for my wife she was on daily doses of morphine and it was building up in her system too much. Insurance kept saying they need more reasons to switch meds.

  7. Adrenergic blocking agent - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_blocking_agent

    However, the serotonin receptor antagonism has side effects such as weight gain and impaired movement. [11] Hence, alpha-2 blockers are not used clinically due to its extensive binding. Similar to the alpha-1 blocker, the alpha-2 family will also present the first-dose effect , but it is generally less pronounced compared with the alpha-1 blockers.

  8. 13 Things You Should Never, Ever Carry in Your Wallet - AOL

    www.aol.com/finance/13-things-never-ever-carry...

    5. Excess Cash. Walking around with a fat wallet of cash feels good, but if you lose your wallet, the odds of keeping your green aren’t good. Besides, if you’re out and about and a potential ...

  9. This Christmas, ask for genetic testing. It could save your life.

    www.aol.com/christmas-ask-genetic-testing-could...

    Patients are typically offered testing if they have either a personal or family history of cancer that meets certain criteria, Zakalik adds. Those criteria have broadened over the last few years ...

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