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A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
The transactivation domain or trans-activating domain (TAD) is a transcription factor scaffold domain which contains binding sites for other proteins such as transcription coregulators.
Illustration of an activator. In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
Transcriptional repression in cancer can also occur by other epigenetic mechanisms, such as altered expression of microRNAs. [60] In breast cancer, transcriptional repression of BRCA1 may occur more frequently by over-expressed microRNA-182 than by hypermethylation of the BRCA1 promoter (see Low expression of BRCA1 in breast and ovarian cancers).
The activator bound coactivator recruits RNA polymerase and other transcription machinery that then begins transcribing the target gene. A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. [1]
103806 Ensembl ENSG00000161021 ENSMUSG00000050567 UniProt Q92585 Q6T264 RefSeq (mRNA) NM_014757 NM_175334 RefSeq (protein) NP_055572 NP_780543 NP_001388483 Location (UCSC) Chr 5: 179.73 – 179.78 Mb Chr 11: 50.15 – 50.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene. Function This protein is the ...
CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression.. CREB-TF (CREB, cAMP response element-binding protein) [1] is a cellular transcription factor.
Enhancers are bound by transcription activator proteins and transcriptional regulation is typically controlled by more than one activator. Enhanceosomes are formed in special cases when these activators cooperatively bind together along the enhancer sequence to create a distinct three-dimensional structure.