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Micrograph showing gliosis in the cerebellum. Reactive astrocytes on the left display severe proliferation and domain overlap. Reactive astrogliosis is the most common form of gliosis and involves the proliferation of astrocytes, a type of glial cell responsible for maintaining extracellular ion and neurotransmitter concentrations, modulating synapse function, and forming the blood–brain ...
Cell replacement strategies are now intensely studied as a possible therapeutic intervention of glial associated neurodegenerative disorders and glial tumors. Similar to any novel strategy, however, set-backs and liabilities accompany the promises this technique withholds.
A glial scar formation is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system.As with scarring in other organs and tissues, the glial scar is the body's mechanism to protect and begin the healing process in the nervous system.
Although glial cells and neurons were probably first observed at the same time in the early 19th century, unlike neurons whose morphological and physiological properties were directly observable for the first investigators of the nervous system, glial cells had been considered to be merely "glue" that held neurons together until the mid-20th ...
Rosenthal fibers. H&E staining showing these elongated eosinophilic structures in a case of pilocytic astrocytoma.Magnification 400x. A Rosenthal fiber is a thick, elongated, worm-like or "corkscrew" eosinophilic (pink) bundle that is found on staining of brain tissue in the presence of long-standing gliosis, occasional tumors, and some metabolic disorders.
Gliosis and glial scar are the same thing. the more common medical term is gliosis. it is permanent. —Preceding unsigned comment added by 128.36.152.126 02:39, 22 November 2010 (UTC) The terms gliosis and microgliosis are also being used to describe microglial and astrocyte abnormalities in chronic pain syndromes.
Astrocytes can also respond to CNS injury by undergoing reactive gliosis. This acts as a neuroprotective event by upregulating intermediate filament proteins for structural cellular support. One of these proteins, glial fibrillary acidic protein (GFAP) can be used as a marker for reactive gliosis in damaged tissue.
Radial glial cells, or radial glial progenitor cells (RGPs), are bipolar-shaped progenitor cells that are responsible for producing all of the neurons in the cerebral cortex. RGPs also produce certain lineages of glia , including astrocytes and oligodendrocytes .