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An oocyte is produced in a female fetus in the ovary during female gametogenesis. The female germ cells produce a primordial germ cell (PGC), which then undergoes mitosis, forming oogonia. During oogenesis, the oogonia become primary oocytes. An oocyte is a form of genetic material that can be collected for cryoconservation.
In fact, a primary oocyte is, by its biological definition, a cell whose primary function is to divide by the process of meiosis. [16] However, although this process begins at prenatal age, it stops at prophase I. In late fetal life, all oocytes, still primary oocytes, have halted at this stage of development, called the dictyate.
The primary oocyte is defined by its process of ootidogenesis, which is meiosis. [2] It has duplicated its DNA, so that each chromosome has two chromatids, i.e. 92 chromatids all in all (4C). When meiosis I is completed, one secondary oocyte and one polar body is created. Primary oocytes have been created in late fetal life.
At puberty, one primary oocyte will continue meiosis each menstrual cycle. Because there is an absence of regenerating germ cells and oogonia in the human, the number of primary oocytes dwindles after each menstrual cycle until menopause , when the female no longer has a population of primary oocytes.
Once the primary oocytes stop dividing the cells enter a prolonged 'resting phase'. This 'resting phase' or dictyate stage can last anywhere up to fifty years in the human. For several primary oocytes that complete meiosis I each month, only one or a few functional oocyte, the dominant follicles, completes maturation and undergoes ovulation ...
Folliculogenesis is continuous, meaning that at any time the ovary contains follicles in many stages of development. The majority of follicles die and never complete development. A few develop fully to produce a secondary oocyte which is released by rupture of the follicle in a process called ovulation.
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Ovulation is the regular release of one oocyte from the ovary into the reproductive tract and is preceded by follicular growth. A few follicle cells are stimulated to grow but only one oocyte is ovulated. A primordial follicle consists of an epithelial layer of follicular granulosa cells enclosing an oocyte.