Search results
Results from the WOW.Com Content Network
Artificial skin is a collagen scaffold that induces regeneration of skin in mammals such as humans. The term was used in the late 1970s and early 1980s to describe a new treatment for massive burns. It was later discovered that treatment of deep skin wounds in adult animals and humans with this scaffold induces regeneration of the dermis. [1]
Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. [3] In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and 6% by weight of skeletal muscle. [4] The fibroblast is the most common cell creating collagen in animals.
Type IV collagen is a type of collagen that is responsible for providing a scaffold for stability and assembly. It is also predominantly found in extracellular basement membranes. [ 3 ] It aids in cell adhesion , migration , survival , expansion, and differentiation .
Healthy cartilage is removed from the person's own knees and a 'scaffold' is created on which the healthy tissue growths. [1] This is an autologous matrix-induced chondrogenesis procedure which prevents tissue rejection complications since the transplanted cartilage comes from the same person.
In biology, the extracellular matrix (ECM), [1] [2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.
These scaffolds encompass natural scaffolds (e.g., decellularized kidneys, [106] collagen hydrogel, [107] [108] or silk fibroin [109]), synthetic scaffolds (e.g., poly[lactic-co-glycolic acid] [110] [111] or other polymers), or a combination of two or more natural and synthetic scaffolds. These scaffolds can be implanted into the body either ...
Newman et al. (2006) inserted conductive and non-conductive fibers into a collagen-TERP scaffold (collagen cross-linked with a terpolymer of poly(N-isopropylacrylamide) (PNiPAAm) ). The fibers were embedded by tightly wrapping them on a small glass slide and sandwiching a collagen-TERP solution between it and another glass slide; spacers ...
Compound collagen-based scaffolds have been developed in an attempt to improve the function of these scaffolds for tissue engineering. An example of a compound collagen scaffold is the collagen-chitosan matrix. Chitosan is a polysaccharide that is chemically similar to cellulose. Unlike collagen, chitosan biodegrades relatively slowly.