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The rare simultaneous occurrence of thrombocytopenia (low blood platelets) with blood clots after vaccination raised the original concern about this condition. [citation needed] In many cases where acute thrombosis and thrombocytopenia have been found together after COVID‑19 vaccination, an antibody against platelet factor 4 has been ...
The CDC has issues special guidance for the specific post-vaccine clots, known as vaccine-induced immune thrombotic thrombocytopenia, or VITT.
There were no associations with blood clots in an artery (arterial thromboembolism) for either vaccine, but there were some 5,000 excess events per 10 million people infected with Covid, they said.
A January 2024 study by the CDC found that staying up to date on the vaccines could reduce the risk of strokes, blood clots and heart attacks related to COVID-19 in people aged 65 years or older or with a condition that makes them more vulnerable to said conditions. [411] [412]
[30] [85] This syndrome, marked by formation of blood clots in the blood vessels in combination with low levels of blood platelets 4–28 days after the vaccines administration, occurred at a rate of about 7 per 1 million vaccinated women aged 18–49 years old and it occurs more rarely in other populations (i.e., women 50 years and older and ...
This results in platelet activation and the formation of platelet microparticles, which initiate the formation of blood clots; the platelet count falls as a result, leading to thrombocytopenia. [1] [7] In addition, the reticuloendothelial system (mostly the spleen) removes the antibody-coated platelets, further contributing to the thrombocytopenia.
These then bind their respective receptors on platelet surfaces, in both an autocrine and paracrine fashion (binds both itself and other platelets). The binding of these receptors result in a cascade of events resulting in an increase in intracellular calcium (e.g. via G q receptor activation leading to Ca 2+ release from platelet endoplasmic ...
The DHPC indicated that a causal relationship between the vaccine and blood clots in combination with low blood platelets (thrombocytopenia) was plausible and identified it as a very rare side effect of the vaccine. [222] According to the EMA these very rare adverse events occur in around 1 out of 100,000 vaccinated people.
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