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2,4-Dinitrophenol (2,4-DNP or simply DNP) is an organic compound with the formula HOC 6 H 3 (NO 2) 2. It has been used in explosives manufacturing and as a pesticide and herbicide. In humans, DNP causes dose-dependent mitochondrial uncoupling , causing the rapid loss of ATP as heat and leading to uncontrolled hyperthermia —up to 44 °C (111 ...
2,4-Dinitrophenol (DNP) is a very strong thermogenic drug used for fat loss which produces a dose-dependent increase in body temperature, to the point where it can induce death by hyperthermia. It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain .
There are six isomers of dinitrophenol: Chemical structure of 2,4-Dinitrophenol. 2,3-Dinitrophenol; 2,4-Dinitrophenol; 2,5-Dinitrophenol; 2,6-Dinitrophenol; 3,4-Dinitrophenol; 3,5-Dinitrophenol; Dinitrophenols also form the core structure of some herbicides, which are collectively referred to as dinitrophenol herbicides, including: Chemical ...
2,4-Dinitrophenol, a small organic molecule formerly marketed as a pharmaceutical "diet aid" 2,4-Dinitrophenylhydrazine , Brady's reagent, used in organic chemical analysis Topics referred to by the same term
It had a modest effect but produced the symptoms of hyperthyroidism as a side effect, such as palpitations and difficulty sleeping. [36] 2,4-Dinitrophenol (DNP) was introduced in 1933; this worked by uncoupling the biological process of oxidative phosphorylation in mitochondria, causing them to produce heat instead of ATP.
2,4-Dinitrophenol, a small organic molecule formerly marketed as a pharmaceutical "diet aid"; Deoxyribonucleoprotein, a complex of DNA and protein; Distance to neutral point, a quantity which is important when considering thermal expansion mismatch
"The lowest published lethal human oral dose of DNP is 4.3 mg/kg"2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death, however "In studies of intermediate-duration oral exposure to 2,4-DNP, cases of death from agranulocytosis (described in the discussion of Hematological Effects) have been attributed to ...
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