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  2. Gastrointestinal perforation - Wikipedia

    en.wikipedia.org/wiki/Gastrointestinal_perforation

    The gastrointestinal wall is composed of four layers surrounding a central lumen. Gastrointestinal perforation is defined by a full-thickness injury to all layers of the gastrointestinal wall, resulting in a hole in the hollow GI tract (esophagus, stomach, small intestine, or large intestine). A hole can occur due to direct mechanical injury or ...

  3. Endoscopic retrograde cholangiopancreatography - Wikipedia

    en.wikipedia.org/wiki/Endoscopic_retrograde_cho...

    [citation needed] A systematic review of clinical trials concluded that a previous history of PEP or pancreatitis significantly increases the risk for PEP to 17.8% and to 5.5% respectively. [20] [21] Intestinal perforation is a risk of any gastroenterologic endoscopic procedure, and is an additional risk if a sphincterotomy is performed.

  4. Alosetron - Wikipedia

    en.wikipedia.org/wiki/Alosetron

    The phase III trial for approval was published in 2000 as an industry-funded randomized, placebo-controlled trial (PCT). Its authors found 1 mg alosetron, taken orally twice daily for 12 weeks, was associated with a 12% (CI 4.7-19.2) improvement in relief from abdominal pain and discomfort associated with diarrhea-predominant patients. [4]

  5. Acute abdomen - Wikipedia

    en.wikipedia.org/wiki/Acute_abdomen

    Common causes of an acute abdomen include a gastrointestinal perforation, peptic ulcer disease, mesenteric ischemia, acute cholecystitis, appendicitis, diverticulitis, pancreatitis, and an abdominal hemorrhage. However, this is a non-exhaustative list and other less common causes may also lead to an acute abdomen. [2]

  6. Colonoscopy - Wikipedia

    en.wikipedia.org/wiki/Colonoscopy

    The large randomized pragmatic clinical trial NordICC was the first published trial on the use of colonoscopy as a screening test to prevent colorectal cancer, related death, and death from any cause. It included 84,585 healthy men and women aged 55 to 64 years in Poland, Norway, and Sweden, who were randomized to either receive an invitation ...

  7. Diverticulitis - Wikipedia

    en.wikipedia.org/wiki/Diverticulitis

    The risk of complications, such as peritonitis or perforation, is greater during the first episode of diverticulitis, and the risk reduces with each recurrence. People who are immunocompromised have a 5-fold increased risk of recurrence with complications, such as bowel perforation, compared to immunocompetent people.

  8. Matthew Perry Opened Up About His Near-Death Experience in ...

    www.aol.com/entertainment/matthew-perry-opened...

    Perry recalled suffering a gastrointestinal perforation when his colon burst from opioid overuse. the actor fought for his life and wound up having to use a colostomy bag for nine months. Perry ...

  9. Organ perforation - Wikipedia

    en.wikipedia.org/wiki/Organ_perforation

    Organ perforation is a complete penetration of the wall of a hollow organ in the body, such as the gastrointestinal tract in the case of gastrointestinal perforation. It mainly refers to accidental or pathologic perforation, rather than intentional penetration during surgery.