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In analytical chemistry, the detection limit, lower limit of detection, also termed LOD for limit of detection or analytical sensitivity (not to be confused with statistical sensitivity), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%).
A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
Using a spectrophotometer, it is possible to quantitatively determine the nitrite concentration. The detection limit of the Griess test generally ranges between 0.02 and 2 μM, depending on the exact details of the specific components used in the Griess reagent. [3]
A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL) A general method for analysis of concentration involves the creation of a calibration curve. This allows for the determination of the amount of a chemical in a material by comparing the results of an unknown ...
Because of the complex inter-relationship between analytical method, sample concentration, limits of detection and method precision, the management of Analytical Quality Control is undertaken using a statistical approach to determine whether the results obtained lie within an acceptable statistical envelope.
Stripping analysis has the following properties: sensitive and reproducible (RSD<5%) method for trace metal ion analysis in aqueous media, 2) concentration limits of detection for many metals are in the low ppb to high ppt range (S/N=3) and this compares favorably with AAS or ICP analysis, field deployable instrumentation that is inexpensive ...
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The detection limit, often referred to as the Minimum Detectable Activity (MDA), is given by the formula: M D A = 2.707 + 4.65 N E T {\displaystyle MDA={\frac {2.707+4.65{\sqrt {N}}}{ET}}} ...where N is the number of counts of background in the region of interest; E is the counting efficiency; and T is the counting time.