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A lung nodule or pulmonary nodule is a relatively small focal density in the lung. A solitary pulmonary nodule (SPN) or coin lesion, [1] is a mass in the lung smaller than three centimeters in diameter. A pulmonary micronodule has a diameter of less than three millimetres. [2] There may also be multiple nodules.
Solitary fibrous tumor (SFT), also known as fibrous tumor of the pleura, is a rare mesenchymal tumor originating in the pleura [1] or at virtually any site in the soft tissue including the seminal vesicle. [2] Approximately 78% to 88% of SFT's are benign and 12% to 22% are malignant. [3]
Minimally invasive adenocarcinoma of the lung (MIA) is defined as a small (≤3 cm), solitary tumour with predominant alveolar epithelial appearance (lepidic growth), as in situ adenocarcinoma of the lung, with a zone of focal invasion of the stroma with a size inferior to 5 mm. [1] For MIA—as with adenocarcinoma in situ—, the prognosis is near 100% survival.
If the measurable disease is restricted to a solitary lesion, its neoplastic nature should be confirmed by cytology/histology. Measurable lesions – lesions that can be accurately measured in at least one dimension with longest diameter ≥20 mm using conventional techniques or ≥10 mm by spiral CT scan .
The 2021 U.S. Preventive Services Task Force guidelines recommend annual screening for lung cancer with low-dose computed tomography in adults aged 50 to 80 years who have a 20 pack-year smoking history and currently smoke or have quit within the past 15 years. [6]
The risk is positively correlated with the size of tumour. [26] Prophylactic cranial irradiation is found to be beneficial in decrease central nervous system recurrence and increase disease-free survival. The risk of brain relapse in limited-stage small cell lung carcinoma is 50% to 60% without prophylactic cranial irradiation.
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