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There was a 5.2% increase in the incidence of hot flushes, 1.6% increase in urinary tract infections, and 0.5% increase in the incidence of headache with ospemifene over placebo. [14] One of the phase 3 trials was a randomized, double-blind placebo-controlled trial in 826 post-menopausal women. [15]
Estropipate, also known as piperazine estrone sulfate and sold under the brand names Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex among others, is an estrogen medication which is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms.
Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [7] [5] [6] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [8] [9] It is an estrogen ester and a prodrug of estradiol in the body.
The brand achieved notoriety as a result of a viral 2006 commercial consisting only of the tagline "HeadOn: Apply directly to the forehead!" repeated three times. An earlier commercial claimed the product provided headache relief but was pulled after objections from the Better Business Bureau. The commercial garnered widespread criticism for ...
Side effects of estrogens like estrone include breast tenderness, breast enlargement, headache, nausea, fluid retention, and edema, among others. [5] Estrone is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor , the biological target of estrogens like endogenous estradiol . [ 5 ]
The medication is available both alone and in combination with an estrogen. [11] [12] It is taken by mouth, used under the tongue, or by injection into a muscle or fat. [10] Common side effects include menstrual disturbances such as absence of periods, abdominal pain, and headaches. [10]