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Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Doxylamine is used in the combination drug pyridoxine/doxylamine to treat morning sickness (nausea and vomiting of pregnancy). [19] [20] [21] It is the only medication approved by the United States Food and Drug Administration for the treatment of morning sickness. [19] [20]
[3] [4] It was introduced as a sedative and medication for morning sickness without having been tested on pregnant women. [5] While initially deemed to be safe in pregnancy, concerns regarding birth defects were noted in 1961, and the medication was removed from the market in Europe that year. [3] [6]
Morning sickness, also called nausea and vomiting of pregnancy (NVP), is a symptom of pregnancy that involves nausea or vomiting. [1] Despite the name, nausea or vomiting can occur at any time during the day. [ 2 ]
Treatments include anti-sickness medicines and steroids, but some women may require hospitalisation and intravenous fluids. Sir Stephen added: “The more sensitive she is to this hormone, the ...
Scientists are moving forward with researching cures for morning sickness, including testing drugs that block GDF15 from binding to its receptor in the brain, and exposing women to the hormone ...
1962: After thalidomide, a medication sometimes used for morning sickness in Europe and Australia, results in more than 10,000 deaths and birth defects in babies, the United States strengthens the ...
Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy. It is typically used after other antiemetic drugs have failed. [17] A large multi-center cohort study found no association between ondansetron exposure and fetal risk compared to other antiemetics. [18]
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