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Guanidine exists protonated, as guanidinium, in solution at physiological pH. Guanidinium chloride (also known as guanidine hydrochloride) has chaotropic properties and is used to denature proteins. Guanidinium chloride is known to denature proteins with a linear relationship between concentration and free energy of unfolding.
This dosage may be gradually increased to a total daily dosage of 35 mg/kg (16 mg/pound) of body weight per day or up to the development of side effects. Side effects may include increased peristalsis, diarrhea, paresthesia (tingling and numbness), and nausea. Fatal bone-marrow suppression, apparently dose related, can occur with guanidine. [7]
Tetramethylguanidine is mainly used as a strong, non-nucleophilic base for alkylations, often as a substitute for the more expensive DBU and DBN. [3] Since it is highly water-soluble, it is easily removed from mixtures in organic solvents. It is also used as a base-catalyst in the production of polyurethane. [4]
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β-Guanidinopropionic acid, also referred to as guanidinopropionic acid, beta-guanidinopropionic acid or β-GPA, is a dietary supplement.. β-Guanidinopropionic acid, also known as Ompenaclid (RGX-202), is being investigated in colorectal cancer by Inspirna and Merck [2]
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Kettlebell training “can be a total body workout,” says Albert Matheny, RD, CSCS, co-founder of SoHo Strength Lab. “You can do strength training, cardio—a mix of stuff,” he continues.
The last of these is not pre-formulated, but rather is generated at the time of use by combining a cream containing calcium hydroxide (slaked lime) with an "activating solution" of guanidine carbonate. Another type of "no-lye" relaxer uses ammonium thioglycolate, which is also known as perm salt for its use in permanent waves.