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It comes as mycophenolate sodium and mycophenolate mofetil. [13] Common side effects include nausea, infections, and diarrhea. [13] Other serious side effects include an increased risk of cancer, progressive multifocal leukoencephalopathy, anemia, and gastrointestinal bleeding. [13] Use during pregnancy may harm the baby. [13]
Although it is a structural analogue of tacrolimus, it acts somewhat differently and has different side-effects. Contrary to ciclosporin and tacrolimus, drugs that affect the first phase of T lymphocyte activation, sirolimus affects the second phase, namely signal transduction and lymphocyte clonal proliferation.
This was the first antibiotic compound isolated in pure and crystallised form. Though the original compound was abandoned in clinical practice due to its adverse effects, its chemical derivative mycophenolate mofetil became the drug of choice as an immunosuppressant in kidney, heart, and liver transplantations. [3]
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Azathioprine is used alone or in combination with other immunosuppressive therapy to prevent rejection following organ transplantation, and to treat an array of autoimmune diseases, including rheumatoid arthritis, pemphigus, systemic lupus erythematosus, Behçet's disease, and other forms of vasculitis, autoimmune hepatitis, atopic dermatitis, myasthenia gravis, neuromyelitis optica (Devic's ...
Side effects can be severe and include infection, cardiac damage, hypertension, blurred vision, liver and kidney problems (tacrolimus nephrotoxicity), [26] hyperkalemia, hypomagnesemia, hyperglycemia, diabetes mellitus, itching, lung damage (sirolimus also causes lung damage), [27] and various neuropsychiatric problems such as loss of appetite ...
Severe side effects may include suicide and psychosis. [ 8 ] [ 7 ] Use during pregnancy may result in harm to the fetus. [ 9 ] Primidone is an anticonvulsant of the barbiturate class; [ 7 ] however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital . [ 10 ]
Many side effects and adverse drug reactions have been reported with oral terbinafine hydrochloride, [13] [14] possibly due to its extensive biodistribution and the often extended durations involved in antifungal treatment (longer than two months). A comprehensive list of adverse events associated with terbinafine use includes:
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