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Cluster headache is a neurological disorder characterized by recurrent severe headaches on one side of the head, typically around the eye(s). [1] There is often accompanying eye watering, nasal congestion, or swelling around the eye on the affected side. [1]
The three most common types are tension headaches, migraines and cluster headaches, according to Cohen. "Tension headaches are among the most frequent types and are what most people consider a ...
Methysergide, sold under the brand names Deseril and Sansert, is a monoaminergic medication of the ergoline and lysergamide groups which is used in the prophylaxis and treatment of migraine and cluster headaches. [2] It has been withdrawn from the market in the United States and Canada due to safety concerns. [3] It is taken by mouth. [3]
Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. [1] It is taken orally, intranasally, or by subcutaneous injection. [2] Therapeutic effects generally occur within three hours. [2]
The drugs of this class act as agonists for serotonin 5-HT 1B and 5-HT 1D receptors at blood vessels and nerve endings in the brain. The first clinically available triptan was sumatriptan, which has been marketed since 1991. Triptans have largely replaced ergotamines, an older class of medications used to relieve migraine and cluster headaches. [3]
Treatment for TACs varies depending on the exact type, but can include medication such as Indomethacin (in the case of chronic paroxysmal hemicrania) or acute and prophylactic therapy (in the case of cluster headache). [4]
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