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Phagocytosis (from Ancient Greek φαγεῖν (phagein) 'to eat' and κύτος (kytos) 'cell') is the process by which a cell uses its plasma membrane to engulf a large particle (≥ 0.5 μm), giving rise to an internal compartment called the phagosome. It is one type of endocytosis. A cell that performs phagocytosis is called a phagocyte.
When a phagocyte ingests bacteria (or any material), its oxygen consumption increases. The increase in oxygen consumption, called a respiratory burst, produces reactive oxygen-containing molecules that are anti-microbial. [32] The oxygen compounds are toxic to both the invader and the cell itself, so they are kept in compartments inside the cell.
The resulting molecules can serve as raw materials and energy sources for various cellular processes, potentially including the facilitation of subsequent rounds of phagocytosis. [9] This efficient recycling of engulfed material highlights the phagolysosome's role not only in cellular defense but also in nutrient acquisition and energy management.
The degraded molecules need to be delivered to the cytoplasm; however, this will not be possible if the molecules are not hydrolyzed in the lysosome. [3] Autophagic intracellular digestion is processed in the cell, which means it digests the internal molecules. [3] Functions of autophagy
Respiratory burst (or oxidative burst) is the rapid release of the reactive oxygen species (ROS), superoxide anion (O − 2) and hydrogen peroxide (H 2 O 2), from different cell types. This is usually utilised for mammalian immunological defence, but also plays a role in cell signalling.
Steps of a macrophage ingesting a pathogen: a. Ingestion through phagocytosis, a phagosome is formed b. The fusion of lysosomes with the phagosome creates a phagolysosome; the pathogen is broken down by enzymes c. Waste material is expelled or assimilated (the latter not pictured) Parts: 1. Pathogens 2. Phagosome 3. Lysosomes 4. Waste material ...
The reactions involved in respiration are catabolic reactions, which break large molecules into smaller ones, producing large amounts of energy (ATP). Respiration is one of the key ways a cell releases chemical energy to fuel cellular activity. The overall reaction occurs in a series of biochemical steps, some of which are redox reactions.
Phagocytosis of a bacterium, showing the formation of phagosome and phagolysosome In cell biology , a phagosome is a vesicle formed around a particle engulfed by a phagocyte via phagocytosis . Professional phagocytes include macrophages , neutrophils , and dendritic cells (DCs).