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Human chorionic gonadotropin is a glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa, approximately 14.5kDa αhCG and 22.2kDa βhCG. [4]It is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and a β (beta) subunit that is unique to hCG.
Human chorionic gonadotropin (hCG) is an autocrine growth factor for the blastocyst, while insulin-like growth factor 2, stimulates its invasiveness. [30] Human chorionic gonadotropin not only acts as an immunosuppressive, but also signals to the mother that she is pregnant , preventing luteolysis of the corpus luteum and menstruation by ...
A low dose of human chorionic gonadotropin (HCG) may be injected after completed ovarian stimulation. Ovulation will occur between 24 and 36 hours after the HCG injection. [35] By contrast, induced ovulation in some animal species occurs naturally, ovulation can be stimulated by coitus. [36]
The presence of hCG in a woman's body indicates that a fertilized egg has implanted in the uterus and the placenta has started to form. 10 days after fertilization, significant hCG can be detected from woman's blood sample. [6] The levels of hCG in the body increase rapidly in the first few weeks of pregnancy, doubling every 48–72 hours. [7]
The embryo upregulates hCG, drives growth of the cell, and upregulates P4 production driving development. hCG and P4 direct changes in the mother to enable successful pregnancy (see below) via upregulation of specific hormones that act to direct both endocrinological and biological changes within the mother for successful pregnancy.
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The granulosa lutein cells do have aromatase, and use it to produce estrogens, using the androgens previously synthesized by the theca lutein cells, as the granulosa lutein cells in themselves do not have the 17α-hydroxylase or 17,20 lyase to produce androgens. [5] Once the corpus luteum regresses the remnant is known as corpus albicans. [12]
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