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The endothelium (pl.: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. [1] The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
It begins with an inciting event at the level of the vasculature, probably the endothelium. The inciting event is yet to be elucidated, but may be a viral agent, oxidative stress, or autoimmune. Endothelial cell damage and apoptosis ensue, leading to the vascular leakiness that manifests in early clinical stages as tissue oedema.
Because of the infusion of lipids into the sub-endothelium, the repair has to end up with altered remodeling of the local endothelium. This is the manifestation of a misrepair. This altered remodeling increases the susceptibility of the local endothelium to damage and reduces its repair efficiency.
Endothelial dysfunction may be involved in the development of atherosclerosis [5] [6] [7] and may predate vascular pathology. [5] [8] Endothelial dysfunction may also lead to increased adherence of monocytes and macrophages, as well as promoting infiltration of low-density lipoprotein (LDL) in the vessel wall. [9]
The most common treatments are medications and surgery to repair the damaged blood vessels in your brain. Valvular heart disease Heart valve problems may be treated with medications or surgery.
Within the cardiovascular system such as lining capillaries or the inside of the heart, simple squamous epithelium is specifically called the endothelium. [3] Cells are flat with flattened and oblong nuclei. It is also called pavement epithelium due to its tile-like appearance. This epithelium is associated with filtration and diffusion.
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