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This means the brain-to-body mass ratio is, on average, approximately the same for both sexes. [85] [86] Comparing a male and a female of the same body size, an average difference of 100 grams in brain-mass is present, the male having the bigger and heavier brain. This difference of 100 grams applies over the whole range of human sizes.
The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.
It was found that the group of men slightly outperformed the women in both the verbal-numerical reasoning and reaction time tests. Subsequently, the researchers tested to what extent the differences in performance was mediated by the varying attributes of the male and female brain (e.g. surface area) using two mixed sample groups.
A scanner used to measure bone density using dual energy X-ray absorptiometry. Bone density, or bone mineral density, is the amount of bone mineral in bone tissue.The concept is of mass of mineral per volume of bone (relating to density in the physics sense), although clinically it is measured by proxy according to optical density per square centimetre of bone surface upon imaging. [1]
Brain size is known to differ between men and women, for example (men on average have larger bodies than women), but without well documented differences in IQ. [46] A 2017 study found that the brains of women have a higher density of grey matter, which could compensate for the loss of volume. [53]
The most important risk factors for osteoporosis are advanced age (in both men and women) and female sex; estrogen deficiency following menopause or surgical removal of the ovaries is correlated with a rapid reduction in bone mineral density, while in men, a decrease in testosterone levels has a comparable (but less pronounced) effect. [33] [34]
Adverse effects on bone mineralization are a potential risk of pubertal suppression in gender dysphoric youth treated with GnRH agonists. [48] [73] To protect against lower bone density, doctors recommend exercise, calcium, and Vitamin D. [74] Despite their benefits, there are some considerations regarding the short-term use of puberty blockers.
A 2018 Swedish systematic review found that GnRH modulators had similar pain-relieving effects to gestagen, but also decreased bone density. [ 117 ] Aromatase inhibitors are medications that block the formation of estrogen and have become of interest for researchers who are treating endometriosis. [ 157 ]