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Neuroglycopenia is a shortage of glucose (glycopenia) in the brain, usually due to hypoglycemia. Glycopenia affects the function of neurons, and alters brain function and behavior. Prolonged or recurrent neuroglycopenia can result in loss of consciousness, damage to the brain, and eventual death. [1] [2] [3]
Consciousness can be altered or even lost in extreme cases, leading to coma, seizures, or even brain damage and death. In patients with diabetes, this may be caused by several factors, such as too much or incorrectly timed insulin, too much or incorrectly timed exercise (exercise decreases insulin requirements) or not enough food (specifically ...
A brain injury can cause seizure(s) because of the unusual amount of energy that is discharged across of the brain when the injury occurs and thereafter. A disruption of the supply of oxygen may cause damage to the temporal lobe of the brain. [35] The risk of seizure(s) from a closed head injury is about 15%. [36]
Symptoms and effects can be mild, moderate or severe, depending on how low the glucose falls and a variety of other factors. It is rare but possible for diabetic hypoglycemia to result in brain damage or death. Indeed, an estimated 2–4% of deaths of people with type 1 diabetes mellitus have been attributed to hypoglycemia. [2] [3]
In addition to memory loss, seizures can result in a complete loss of consciousness. pressureUA/iStock via Getty Images PlusEpilepsy is a disease marked by recurrent seizures, or sudden periods of ...
Complications may include seizures, disseminated intravascular coagulopathy, mesenteric artery occlusion, or rhabdomyolysis. [2] The main risk factor is a history of diabetes mellitus type 2. [4] Occasionally it may occur in those without a prior history of diabetes or those with diabetes mellitus type 1.
The most severe risks of insulin coma therapy were death and brain damage, resulting from irreversible or prolonged coma respectively. [1] [7] A study at the time claimed that many of the cases of brain damage were actually therapeutic improvement because they showed "loss of tension and hostility". [15]
Glucose is the main source of energy for the brain, and a number of mechanisms are in place to prevent hypoglycemia and protect energy supply to the brain. [ 3 ] [ 17 ] The body can adjust insulin production and release, adjust glucose production by the liver , and adjust glucose use by the body.
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