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The structure of the sarcomere affects its function in several ways. The overlap of actin and myosin gives rise to the length-tension curve, which shows how sarcomere force output decreases if the muscle is stretched so that fewer cross-bridges can form or compressed until actin filaments interfere with each other. Length of the actin and ...
Sliding filament theory: A sarcomere in relaxed (above) and contracted (below) positions. The sliding filament theory explains the mechanism of muscle contraction based on muscle proteins that slide past each other to generate movement. [1]
It is thought that the myomesin-titin interaction is vital for the execution of the mechanical functions of the Ser/Thr kinase domain of titin. [2] Myomesin is a protein family found in the M-line of the sarcomere structure. Myomesin has various forms throughout the body in striated muscles with specialized functions.
Costameres have several primary functions. [8] [9] [10] First, they keep the sarcolemma in line with the sarcomere during contraction and subsequent relaxation. [10]They are also responsible for the lateral transmission of the sarcomere-generated contractile force to the sarcolemma and the extracellular matrix.
Desmin-related myofibrillar myopathy (DRM or desminopathy) is a subgroup of the myofibrillar myopathy diseases [27] and is the result of a mutation in the gene that codes for desmin which by changing the protein structure [28] prevents it from forming protein filaments, and rather, forms aggregates of desmin and other proteins throughout the cell.
A myofibril (also known as a muscle fibril or sarcostyle) [1] is a basic rod-like organelle of a muscle cell. [2] Skeletal muscles are composed of long, tubular cells known as muscle fibers, and these cells contain many chains of myofibrils. [3]
cMyBP-C is not essential for sarcomere formation during embryogenesis, but is crucial for sarcomere organization and maintenance of normal cardiac function.Absence of cMyBP-C (Mybpc3-targeted knock-out mice) results in severe cardiac hypertrophy, increased heart-weight-to-body-weight-ratios, enlargement of ventricles, increased myofilament Ca2+ sensitivity and depressed diastolic and systolic ...
It is a very large protein (600–900 kDa) and binds as many as 200 actin monomers. Because its length is proportional to thin filament length, it is believed that nebulin acts as a thin filament "ruler" and regulates thin filament length during sarcomere assembly. [6] Other functions of nebulin, such as a role in cell signaling, remain uncertain.