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Nitrofurantoin is concentrated in the urine, leading to higher and more effective levels in the urinary tract than in other tissues or compartments. [45] With a 100 mg oral dose, plasma levels are typically less than 1 μg/mL while in the urine it reaches 200 μg/mL. [57]
Nitroxoline is an antibiotic [1] that has been in use in Europe for about fifty years, and has proven to be very effective at combating biofilm infections. Nitroxoline was shown to cause a decrease in the biofilm density of P. aeruginosa infections, which would allow access to the infection by the immune system in vivo. [2]
Cefixime, sold under the brand name Suprax among others, is an antibiotic medication used to treat a number of bacterial infections. [5] These infections include otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and Lyme disease. [5]
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Minocycline is available in the form of 50 and 100 mg oral capsules, among a variety of other formulations. [6] [36] The oral form of minocycline is usually taken twice daily, once every 12 hours, although divided doses four times daily can also be employed. [6] Extended-release oral forms are also available. [36]
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