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High doses of oral corticosteroids. Antiepileptic drugs (phenobarbital and hydantoin derivatives) Cyclosporin A. Antimycotics. Gold salts. Isotretinoin (an anti-acne drug that can cause an initial ...
Spironolactone is an acne treatment prescribed by dermatologists. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Everything I Wish I Knew About ...
There are also several oral contraceptives that are also FDA-approved to treat hormonal acne and are sometimes prescribed in conjunction with spironolactone. They work by regulating your hormones ...
[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [64] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
The effectiveness of spironolactone for acne appears to be dose-dependent. [117] High-dose cyproterone acetate alone reportedly decreases acne symptoms in women by 75 to 90% within three months. [128] It is usually combined with an estrogen to avoid menstrual irregularities and estrogen deficiency. [129]
A study found that oral spironolactone had "about 10 to 20% of the feminizing effect of cyproterone acetate" on sexual differentiation in male rat fetuses, with a dose of 40 mg/day spironolactone having an effect equal to 1–3 mg/day cyproterone acetate. [35] [36]
Prescription and in-office treatments for chin acne: Dr. Kobets says oral antibiotics ... Spironolactone Oral Acne Medication. nurx.com. $30.00. Spironolactone Hormonal Acne Treatment.
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]