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Hypogammaglobulinemia is an immune system disorder in which not enough gamma globulins are produced in the blood (thus hypo-+ gamma + globulin + -emia).This results in a lower antibody count, which impairs the immune system, increasing risk of infection.
This shows the levels of albumin and the different immunoglobulins. The serum protein electrophoresis test measures the number of proteins in the serum part of a blood sample. The normal ranges to check for the serum globulin would be about 2.0 to 3.5 grams per deciliter then for the immunoglobulins A, M, and G have different ranges.
This may also be called standard range. In contrast, optimal (health) range or therapeutic target is a reference range or limit that is based on concentrations or levels that are associated with optimal health or minimal risk of related complications and diseases. For most substances presented, the optimal levels are the ones normally found in ...
When suspected, the diagnosis can be confirmed by laboratory measurement of IgA level in the blood. SIgAD is an IgA level < 7 mg/dL with normal IgG and IgM levels (reference range 70–400 mg/dL for adults; children somewhat less). [10]
IgG deficiency is a form of dysgammaglobulinemia where the proportional levels of the IgG isotype are reduced relative to other immunoglobulin isotypes.. IgG deficiency is often found in children as transient hypogammaglobulinemia of infancy, which may occur with or without additional decreases in IgA or IgM.
The reference range for total protein is typically 60-80g/L. (It is also sometimes reported as "6.0-8.0g/dl"), [ 2 ] but this may vary depending on the method of analysis. Concentrations below the reference range usually reflect low albumin concentration, for instance in liver disease or acute infection .
Normal level % Function Albumins: 3.5–5.0 g/dl: 55%: create and maintain osmotic pressure; transport insoluble molecules Globulins: 2.0–2.5 g/dl: 38%: participate in immune system: Fibrinogen: 0.2–0.45 g/dl: 7%: Blood coagulation: Regulatory proteins <1%: Regulation of gene expression Clotting factors <1%: Conversion of fibrinogen into fibrin
It is raised in the acute phase response. Depression of C3 occurs in autoimmune disorders as the complement system is activated and the C3 becomes bound to immune complexes and removed from serum. Fibrinogen, a beta-2 protein, is found in normal plasma but absent in normal serum.