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Among all aromatase inhibitors, Letrozole is commonly used for improving female fertility. It works by inhibiting aromatase which is an enzyme that catalyses the conversion of androstenedione and testosterone to estrogen by hydroxylation. Hence, Letrozole inhibits the synthesis of estrogen. [18]
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [ 1 ] It was patented in 1986 and approved for medical use in 1996. [ 4 ]
In the Nordic countries, letrozole is practically the standard initial regimen used for ovulation induction, since no formulation of clomifene is registered for use there. [ 19 ] [ 20 ] India banned the usage of letrozole in 2011, citing potential risks to infants. [ 21 ]
Letrozole is the preferred treatment in those with infertility due to PCOS and is associated with a higher pregnancy rate than other treatments. [2] Both clomiphene and letrozole have a risk of a multiple gestation pregnancy, with the risk being less than 10%. [ 2 ]
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Letrozole has a 1,2,4 triazole ring which is important for binding with Fe 2+ in the heme moiety of the aromatase enzyme. Also, the cyano benzyl moiety is significant because it partly imitates the steroid backbone of the natural hormone androstenedione.
The top line remains unchanged in our updated bracketology, with Auburn, Duke, Alabama and Florida continuing to occupy the No. 1 seeds with less than four weeks left until Selection Sunday.
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