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Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. [ 5 ] [ 6 ] DBP is genetically the oldest member of the albuminoid family and appeared early in the evolution of vertebrates.
Metabolites produced from vitamin D 2 tend to bind less well to the vitamin D-binding protein. [ 3 ] Vitamin D 3 can alternatively be hydroxylated to calcifediol by sterol 27-hydroxylase (CYP27A1), but vitamin D 2 cannot.
Alpha-fetoprotein is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin D-binding protein binds to vitamin D and its metabolites, as well as to fatty acids. Not much is known about afamin. It seems to carry lipidated Wnt proteins and Vitamin E around. [9] Extracellular matrix protein 1 is a less canonical ...
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM).. This list covers carrier proteins.
Ergocalciferol and metabolites have lower affinity to the vitamin D-binding protein compared to the D 3 counterparts. The binding affinity of ercalcitriol to the vitamin D receptor is similar to that of calcitriol. [22] Ergocalciferol itself and metabolites can be deactivated by 24-hydroxylation. [23]
Protein: 17 g. Total Fat: 13 g. Saturated Fat: 6 g. Sodium: 770 mg. 2. McCafé Latte. The McCafé Latte is packed with blood pressure-lowering nutrients like calcium, potassium and vitamin D ...
The second hydroxylation occurs mainly in the kidney through the action of CYP27B1 to convert 25-OH vitamin D 3 into 1,25-dihydroxycholecalciferol (calcitriol, 1,25-(OH) 2 vitamin D 3). All these metabolites are bound in blood to the vitamin D-binding protein.
Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite. [4] [5] Calcifediol has an elimination half-life of around 15 to 30 days. [4] [9] Calcifediol is further hydroxylated at the 1-alpha-position in the kidneys to form 1,25-(OH) 2 D 3, calcitriol.