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Vitamin D-binding protein (DBP), also/originally known as gc-globulin (group-specific component), is a protein that in humans is encoded by the GC gene. [ 5 ] [ 6 ] DBP is genetically the oldest member of the albuminoid family and appeared early in the evolution of vertebrates.
Metabolites produced from vitamin D 2 tend to bind less well to the vitamin D-binding protein. [3] Vitamin D 3 can alternatively be hydroxylated to calcifediol by sterol 27-hydroxylase (CYP27A1), but vitamin D 2 cannot. [3] Ergocalciferol can be directly hydroxylated at position 24 by CYP27A1. [3]
Transcription of the CYP24A1 gene is markedly inducible by 1,25-(OH) 2 D 3 binding to the vitamin D receptor. [6] The gene has a strong, positive vitamin D response element in the promoter . Through regulation of CYP24A1 expression, a negative feedback control system is created to limit the effects of 1,25-(OH) 2 D 3 .
The second hydroxylation occurs mainly in the kidney through the action of CYP27B1 to convert 25-OH vitamin D 3 into 1,25-dihydroxycholecalciferol (calcitriol, 1,25-(OH) 2 vitamin D 3). All these metabolites are bound in blood to the vitamin D-binding protein.
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM).. This list covers carrier proteins.
The AMH gene promoter contains a vitamin D response element that may cause vitamin D status to influence serum AMH levels. Women with levels of vitamin D of 267.8 ± 66.4 nmol/L show a 4 times better success rate with IVF procedure than those with low levels of 104.3 ± 21 nmol/L. Vitamin D deficiency should be considered when serum AMH levels ...
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related to: vitamin d binding protein kit for women- 114 W 3rd Ave, Columbus, OH · Directions · (614) 456-1108
vitaminshoppe.com has been visited by 100K+ users in the past month
1540 Olentangy River Rd, Columbus, OH · Directions · (614) 299-2253