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In 2010, the project finished its pilot phase, which was described in detail in a publication in the journal Nature. [1] In 2012, the sequencing of 1092 genomes was announced in a Nature publication. [2] In 2015, two papers in Nature reported results and the completion of the project and opportunities for future research. [3] [4]
The WHG has been involved in many international statistical genetics advances including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the 1000 Genomes Project and the International HapMap Project. [10]
The McDonnell Genome Institute is located on the Washington University School of Medicine campus in St. Louis, Missouri, at 4444 Forest Park Avenue. It is accessible by Metrolink (Central West End Station). The McDonnell Genome Institute has a separate data center located across the street at 222 Newstead Avenue.
For a long time PHASE [3] was the most accurate method. PHASE was the first method to utilize ideas from coalescent theory concerning the joint distribution of haplotypes. This method used a Gibbs sampling approach in which each individuals haplotypes were updated conditional upon the current estimates of haplotypes from all other samples.
Bradley wanted to build on the achievements made by the Sanger Institute in the Human Genome Project by "concentrating on gene function, cancer genomics, and the genomes of model organisms such as the mouse and the zebrafish". [51] Bradley received his BA, MA and PhD in genetics from the University of Cambridge. [52] [53] [54] [55]
1 from Southern Kalahari, 3 from Northern Kalahari, 1 Bantu from South Africa [3] Singapore: Singapore Genome Variation Project: 268 individuals from the Chinese, Malay, and Indian population groups in Southeast Asia [4] Italy: SardiNIA Project: 2,000 sequenced Sardinian people [5] Germany: PopGen (German) Genotyping of 10,000 German people [6 ...
In October 2006, he was appointed professor of statistical genetics at the University of Oxford. [ 17 ] McVean's research [ 18 ] focuses on population genetics , statistics [ 19 ] and evolutionary biology including the International HapMap Project , [ 20 ] [ 21 ] recombination rates in the human genome [ 22 ] and the 1000 Genomes Project .
In genetics, imputation is the statistical inference of unobserved genotypes. [1] It is achieved by using known haplotypes in a population, for instance from the HapMap or the 1000 Genomes Project in humans, thereby allowing to test for association between a trait of interest (e.g. a disease) and experimentally untyped genetic variants, but whose genotypes have been statistically inferred ...