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Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of condensed genomic DNA to the ... (Chromatin assembly factor-1) ...
To allow the critical cellular process of DNA repair, the chromatin must be remodeled. In eukaryotes, ATP-dependent chromatin remodeling complexes and histone-modifying enzymes are two predominant factors employed to accomplish this remodeling process. [32] Chromatin relaxation occurs rapidly at the site of DNA damage. [33]
In molecular biology, SWI/SNF (SWItch/Sucrose Non-Fermentable), [1] [2] is a subfamily of ATP-dependent chromatin remodeling complexes, which is found in eukaryotes.In other words, it is a group of proteins that associate to remodel the way DNA is packaged.
The S10 phosphorylation is involved in mitosis, transcription, chromatin condensation, and UVB response. [1] H3S10p causes chromosome condensation and segregation during cell mitosis. [2] H3S10p temporarily increases during mitosis while H3K9me3 decreases and H3K9me3 recovers upon mitotic exit. [2] R loops are linked to H3S10P and chromatin ...
There are four subfamilies of chromatin remodelers: SWI/SNF, INO80, ISW1, and CHD. [2] The RSC complex is a 15-subunit chromatin remodeling complex initially found in Saccharomyces cerevisiae, and is homologous to the SWI/SNF complex found in humans. [1] The RSC complex has ATPase activity in the presence of DNA. [1]
For most DNA repair processes, the chromatin must be remodeled. In eukaryotes, ATP-dependent chromatin remodeling complexes and histone-modifying enzymes are two factors that act to accomplish this remodeling process after DNA damage occurs. [60] Further DNA repair steps, involving multiple enzymes, usually follow.
Mitosis in eukaryotes: In mitosis, loop extrusion by condensin is critical for the segregation of sister chromatids and for providing structural rigidity after separation. Condensin I has been found to modulate the size and arrangement of nested inner loops and condensin II organizing the backbone from which loops emanate.
To allow homologous recombination (HR) DNA repair, the chromatin must be remodeled. In eukaryotes, ATP dependent chromatin remodeling complexes and histone-modifying enzymes are two predominant factors employed to accomplish this remodeling process. [34] Chromatin relaxation occurs rapidly at the site of a DNA damage. [35]