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Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of kidney problems, it can occlude the kidneys' filtration system leading to acute tubular necrosis and acute kidney injury. Other causes of myoglobinuria include: McArdle's disease
The myoglobin is filtered by the kidneys, but is toxic to the renal tubular epithelium and so may cause acute kidney injury. [32] It is not the myoglobin itself that is toxic (it is a protoxin ), but the ferrihemate portion that is dissociated from myoglobin in acidic environments (e.g., acidic urine, lysosomes ).
Gastroenteritis, also known as infectious diarrhea, is an inflammation of the gastrointestinal tract including the stomach and intestine. [8] Symptoms may include diarrhea, vomiting, and abdominal pain. [1] Fever, lack of energy, and dehydration may also occur. [2] [3] This typically lasts less than two weeks. [8]
These early symptoms can include diarrhea (which is often bloody), stomach cramps, mild fever, [10] or vomiting that results in dehydration and reduced urine. [9] HUS typically develops about 5–10 days after the first symptoms, but can take up to 3 weeks to manifest, and occurs at a time when the diarrhea is improving. [ 10 ]
Dysentery (UK: / ˈ d ɪ s ən t ər i / DISS-ən-tər-ee, [7] US: / ˈ d ɪ s ən t ɛr i / DISS-ən-terr-ee), [8] historically known as the bloody flux, [9] is a type of gastroenteritis that results in bloody diarrhea. [1] [10] Other symptoms may include fever, abdominal pain, and a feeling of incomplete defecation. [2] [6] [11] Complications ...
Rhabdomyolysis (shortened as rhabdo) is a condition in which damaged skeletal muscle breaks down rapidly, often due to high intensity exercise over a short period. [6] [4] [5] Symptoms may include muscle pains, weakness, vomiting, and confusion.
13350 Ensembl ENSG00000185000 ENSG00000285482 ENSMUSG00000022555 UniProt O75907 Q9Z2A7 RefSeq (mRNA) NM_012079 NM_010046 RefSeq (protein) NP_036211 NP_034176 Location (UCSC) Chr 8: 144.31 – 144.33 Mb Chr 15: 76.39 – 76.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Diacylglycerol O -acyltransferase 1 is an enzyme that in humans is encoded by the DGAT1 gene. Function This gene ...
The most severe symptoms tend to occur in children six months to two years of age, the elderly, and those with immunodeficiency. Due to immunity acquired in childhood, most adults are not susceptible to rotavirus; gastroenteritis in adults usually has a cause other than rotavirus, but asymptomatic infections in adults may maintain the ...