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Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of kidney problems, it can occlude the kidneys' filtration system leading to acute tubular necrosis and acute kidney injury. Other causes of myoglobinuria include: McArdle's disease
These early symptoms can include diarrhea (which is often bloody), stomach cramps, mild fever, [10] or vomiting that results in dehydration and reduced urine. [9] HUS typically develops about 5–10 days after the first symptoms, but can take up to 3 weeks to manifest, and occurs at a time when the diarrhea is improving. [10]
The myoglobin is filtered by the kidneys, but is toxic to the renal tubular epithelium and so may cause acute kidney injury. [32] It is not the myoglobin itself that is toxic (it is a protoxin), but the ferrihemate portion that is dissociated from myoglobin in acidic environments (e.g., acidic urine, lysosomes). [citation needed]
Metmyoglobin is the cause of the characteristic brown colouration of meat that occurs as it ages. In living muscle , the concentration of metmyoglobin is vanishingly small, due to the presence of the enzyme metmyoglobin reductase , which, in the presence of the cofactor NADH and the coenzyme cytochrome b4 converts the Fe 3+ in the heme ...
[6] [4] [5] Symptoms may include muscle pains, weakness, vomiting, and confusion. [3] [4] There may be tea-colored urine or an irregular heartbeat. [3] [5] Some of the muscle breakdown products, such as the protein myoglobin, are harmful to the kidneys and can cause acute kidney injury. [7] [3]
Infections of the lungs or urinary tract in children may also cause vomiting or diarrhea. [1] Classical diabetic ketoacidosis (DKA) presents with abdominal pain, nausea, and vomiting, but without diarrhea. [1] One study found that 17% of children with DKA were initially diagnosed as having gastroenteritis. [1]
For most people, norovirus will cause some unpleasant symptoms, like nausea, vomiting, stomach cramping and diarrhea. The main concern, Nwelue said, is to make sure you’re staying hydrated while ...
Fecal occult blood testing (FOBT), as its name implies, aims to detect subtle blood loss in the gastrointestinal tract, anywhere from the mouth to the colon.Positive tests ("positive stool") may result from either upper gastrointestinal bleeding or lower gastrointestinal bleeding and warrant further investigation for peptic ulcers or a malignancy (such as colorectal cancer or gastric cancer).