Search results
Results from the WOW.Com Content Network
Those with the HLA-B27 variant are at a higher risk than the general population of developing the disorder. HLA-B27, demonstrated in a blood test, can occasionally help with diagnosis, but in itself is not diagnostic of AS in a person with back pain. Over 85% of people that have been diagnosed with AS are HLA-B27 positive, although this ratio ...
Among the Sami in Northern Scandinavia , 24% of people are HLA-B27 positive, while 1.8% have associated ankylosing spondylitis, [3] compared to 14-16% of Northern Scandinavians in general. [ 4 ] [ 5 ] In Finland, an estimated 14% of the population is positive for HLA-B27, while more than 95% of patients with ankylosing spondylitis and ...
Since only 5% of those with HLA-B27 in the general population will develop ankylosing spondylitis, the correlation between HLA-B27 and the prevalence of spondyloarthritis is weak. Therefore, the illness prevalence in a particular population must be taken into account when interpreting results from HLA-B27 testing. [27]
It most commonly strikes individuals aged 20–40 years of age, is more common in men than in women, and is more common in white than in black people. This is owing to the high frequency of the HLA-B27 gene in the white population. [11] [12] It can occur in epidemic form. Patients with HIV have an increased risk of developing reactive arthritis ...
Ankylosing spondylitis: A version of the HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis. It is uncertain how HLA-B27 causes this increased risk. Researchers speculate that HLA-B27 may abnormally display to the immune system peptides that trigger arthritis.
More than 80% of patients with the ankylosing spondylitis variant test positive for the HLA-B27 biomarker, but not everyone with this biomarker will develop disease. [22] Some people with axial spondyloarthritis may test positive for elevated C-reactive protein, or CRP, depending on their disease activity. [22]
Ankylosing spondylitis (AS) is a type of arthritis in which there is long-term inflammation of the joints of the spine. Typically the joints where the spine joins the pelvis are also affected. Occasionally other joints such as the shoulders or hips are involved. [1] John Addey (1920–1982), [2] English astrologer
The result is a catalog of common and well-documented (CWD) HLA alleles, [32] [33] and a catalogue of rare and very rare HLA alleles. [ 30 ] [ 31 ] Common HLA alleles are defined as having been observed with a frequency of at least 0.001 in reference populations of at least 1500 individuals.