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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation.Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die.
It is calculated using the LD50 or LC50. [1] The Occupational Safety and Health Administration (OSHA) regulation (1910.134(b)) defines the term as "an atmosphere that poses an immediate threat to life, would cause irreversible adverse health effects, or would impair an individual's ability to escape from a dangerous atmosphere."
The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
If a mixture contains more than one active constituent, one of the following methods may be used to determine the oral or dermal LD50 of the mixture: Obtain reliable acute oral and dermal toxicity data on the actual mixture to be transported;
The final toxicology report states the fentanyl detected in Heche's urine was administered in the hospital. The medical examiner determined Heche died of inhalation and thermal injuries.
The three Kansas City Chiefs fans who were found dead outside their friend's home on Jan. 9 reportedly had "several substances" in their bodies, family members told a local news outlet.. What’s ...
In toxicology, the median toxic dose (TD 50) of a drug or toxin is the dose at which toxicity occurs in 50% of cases. [1]: 73 The type of toxicity should be specified for this value to have meaning for practical purposes.