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Estrone is an estrogen, specifically an agonist of the estrogen receptors (ERs) ERα and ERβ. [5] [44] It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. [5] [44] Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol. [45]
Women's Estrogen Lipid-Lowering Hormone Atherosclerosis Regression Trial (WELL-HART) Women's Health Initiative Estrogen Study (WHI-E) Women's Health Initiative Estrogen + Progestin Study (WHI-EP) Women's Health, Osteoporosis, Progestin, Estrogen (Women's HOPE) Women's International Study of Long-Duration Oestrogen After Menopause (WISDOM)
Estrogen deprivation therapy, also known as endocrine therapy, is a form of hormone therapy that is used in the treatment of breast cancer.Modalities include antiestrogens or estrogen blockers such as selective estrogen receptor modulators (SERMs) like tamoxifen, selective estrogen receptor degraders like fulvestrant, and aromatase inhibitors like anastrozole and ovariectomy.
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According to a National Institutes of Health study, breast cancer survivors are on these medications for an average of 4.04 years. Minkin says that anywhere from five to 10 years of treatment is ...
Observational studies of systemic HRT after breast cancer are generally reassuring. If HRT is necessary after breast cancer, estrogen-only therapy or estrogen therapy with a progestogen may be safer options than combined systemic therapy. [80] In women who are BRCA1 or BRCA2 mutation carriers, HRT does not appear to impact breast cancer risk. [81]
[198] [201] [202] [203] In accordance with findings with other topical steroids, a study in men with prostate cancer treated with transdermal estradiol patches applied to the scrotum observed about 5-fold higher estradiol levels relative to application to conventional skin sites such as the forearm.
High-dose estrogen therapy is effective in the treatment of about 35% of cases of breast cancer in women who are at least 5 years menopausal and has comparable effectiveness to antiestrogen therapy with medications like the selective estrogen receptor modulator (SERM) tamoxifen.