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There are 209 different chemical compounds in which one to ten chlorine atoms can replace hydrogen atoms. PCBs are typically used as mixtures of compounds and are given the single identifying CAS number 1336-36-3. About 130 different individual PCBs are found in commercial PCB products. [11]: 2 Toxic effects vary depending on the specific PCB.
Humans and wildlife are rarely exposed to solitary contaminants, but rather to complex mixtures of potentially harmful compounds. Dioxins and DLCs are no exception. [ 3 ] This is important to consider when assessing toxicity because the effects of chemicals in a mixture are often different from when acting alone.
PCBs are human carcinogens, and can also have a negative effect on the human immune, reproductive, and endocrine systems. [4] PCBs in the Kalamazoo River adhere to the fatty tissue of fish, and over time a process of bioaccumulation takes place, meaning that the PCBs appear in increasing concentrations in organisms higher up on the food chain ...
Test results conducted in the fall showed the presence of PCBs, or polychlorinated biphenyls — toxic, man-made chemicals that were banned from being produced in the United States in 1979.
Ortho-PCBs may alter hormone regulation through disruption of the thyroid hormone transport by binding to transthyretin. [8] Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs.
The PCB oil leaked to rice bran oil consumed by thousands of people in Japan (Yusho disease 1968) and Taiwan (Yu-cheng disease 1979). The toxic effects have been attributed to dioxin-like PCBs and PCDFs. Their daily intake was up to 100,000 times higher than average intake presently. [1]
(Reuters) -A Washington jury on Tuesday ordered Bayer to pay $100 million to four people who say they were sickened by toxic chemicals known as PCBs at a Seattle-area school, but found the company ...
Exposure to high levels of dioxins in humans causes a severe form of persistent acne, known as chloracne. [34] High occupational or accidental levels of exposures to dioxins have been shown by epidemiological studies to lead to an increased risk of tumors at all sites. [35] Other effects in humans (at high dose levels) may include: