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A photo of human embryonic stem cells (the cell colonies in the center). Spindle cells surrounding the stem cell colony are MEFs. Mouse Embryonic Fibroblasts (MEFs) are a type of fibroblast prepared from mouse embryo. MEFs show a spindle shape when cultured in vitro, a typical feature of fibroblasts. The MEF is a limited cell line.
3T3 cells are several cell lines of mouse embryonic fibroblasts. The original 3T3 cell line (3T3-Swiss albino) was established in 1962 by two scientists then at the Department of Pathology in the New York University School of Medicine, George Todaro and Howard Green .
A fibroblast is a type of biological cell typically with a spindle shape [1] that synthesizes the extracellular matrix and collagen, [2] produces the structural framework for animal tissues, and plays a critical role in wound healing. [3] Fibroblasts are the most common cells of connective tissue in animals.
Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functions compared to the ...
26291 56636 Ensembl ENSG00000105550 ENSMUSG00000030827 UniProt Q9NSA1 Q9JJN1 RefSeq (mRNA) NM_019113 NM_020013 RefSeq (protein) NP_061986 NP_064397 Location (UCSC) Chr 19: 48.76 – 48.76 Mb Chr 7: 45.26 – 45.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 21 (FGF-21) is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this ...
Human iPS cells colonies. The spindle-shaped cells in the background are mouse fibroblast cells. Only those cells comprising the center colony are human iPS cells. Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell.
2006: Japanese scientists Shinya Yamanaka and Kazutoshi Takashi publish a paper describing the induction of pluripotent stem cells from cultures of adult mouse fibroblasts. Induced pluripotent stem cells (iPSCs) are a huge discovery, as they are seemingly identical to embryonic stem cells and could be used without sparking the same moral ...
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. [ 5 ] [ 6 ] It is synthesized as a 155 amino acid polypeptide, whose mature form is a non- glycosylated 17-18 kDa protein.