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Since the original CHO cell line was described in 1956, many variants of the cell line have been developed for various purposes. [10] [additional citation(s) needed] In 1957, CHO-K1 was generated from a single clone of CHO cells. [16] According to an industry source, however, scientist Theodore Puck first isolated CHO-K1 in 1968. [1]
Immortalised cell lines are widely used as a simple model for more complex biological systems – for example, for the analysis of the biochemistry and cell biology of mammalian (including human) cells. [2] The main advantage of using an immortal cell line for research is its immortality; the cells can be grown indefinitely in culture.
The WI-38 cell line stemmed from earlier work by Hayflick growing human cell cultures. [2]In the early 1960s, Hayflick and his colleague Paul Moorhead at the Wistar Institute in Philadelphia, Pennsylvania discovered that when normal human cells were stored in a freezer, the cells remembered the doubling level at which they were stored and, when reconstituted, began to divide from that level to ...
Cellosaurus is an online knowledge base on cell lines, which attempts to document all cell lines used in biomedical research. [1] It is provided by the Swiss Institute of Bioinformatics (SIB). It is an ELIXIR Core Data Resource [ 2 ] [ 3 ] as well as an IRDiRC's Recognized Resource. [ 4 ]
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques.The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". [1]
Dolly was the first clone produced from a cell taken from an adult mammal. [12] [13] The production of Dolly showed that genes in the nucleus of such a mature differentiated somatic cell are still capable of reverting to an embryonic totipotent state, creating a cell that can then go on to develop into any part of an animal. [2]
U.S. officials on Thursday approved drugmaker BioMarin's gene therapy for the most common form of hemophilia, a $2.9 million infused treatment that can significantly reduce dangerous bleeding ...
Human isogenic disease models have been likened to 'patients in a test-tube', since they incorporate the latest research into human genetic diseases and do so without the difficulties and limitations involved in using non-human models. [2] Historically, cells obtained from animals, typically mice, have been used to model cancer-related pathways.