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Gerhard Martin Julius Schmidt (Hebrew: גרהרד מרטין יוליוס שמידט; 21 August 1919 in Berlin – 12 July 1971, in Zurich, buried in Rehovot), was an organic chemist and chemical crystallographer, dean of the chemistry faculty of the Weizmann Institute of Science, and its scientific director in 1969.
Dorothy Mary Crowfoot Hodgkin OM FRS HonFRSC [9] [10] (née Crowfoot; 12 May 1910 – 29 July 1994) was a Nobel Prize-winning English chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became essential for structural biology.
X-ray crystallography of biological molecules took off with Dorothy Crowfoot Hodgkin, who solved the structures of cholesterol (1937), penicillin (1946) and vitamin B 12 (1956), for which she was awarded the Nobel Prize in Chemistry in 1964. In 1969, she succeeded in solving the structure of insulin, on which she worked for over thirty years.
Portrait of William Lawrence Bragg taken when he was around 40 years old. Sir William Lawrence Bragg (31 March 1890 – 1 July 1971), known as Lawrence Bragg, was an Australian-born British physicist and X-ray crystallographer, discoverer (1912) of Bragg's law of X-ray diffraction, which is basic for the determination of crystal structure.
Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of Rosalind Franklin , James Watson , Francis Crick , and Maurice Wilkins on the structure of DNA , which in turn made it possible for geneticists to crack the DNA code of all organisms.
In 1948, Branson took a leave and spent time at the California Institute of Technology, in the laboratory of the chemist Linus Pauling.There he was assigned work on the structure of proteins, specifically to use his mathematical abilities to determine possible helical structures that would fit both the available X-ray crystallography data and a set of chemical restrictions outlined by Pauling. [8]
Crick was in the right place, in the right frame of mind, at the right time (1949), to join Max Perutz's project at the University of Cambridge, and he began to work on the X-ray crystallography of proteins. [30] X-ray crystallography theoretically offered the opportunity to reveal the molecular structure of large molecules like proteins and ...
Firstly they showed that X-ray crystallography could be used to reveal the regular, ordered structure of DNA – an insight which laid the foundations for the later work of Maurice Wilkins and Rosalind Franklin, [1] after which the structure of DNA was identified by Francis Crick and James D. Watson in 1953. Secondly, they did this work at a ...