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In biology, a substrate is the surface on which an organism (such as a plant, fungus, or animal) lives.A substrate can include biotic or abiotic materials and animals. For example, encrusting algae that lives on a rock (its substrate) can be itself a substrate for an animal that lives on top of the algae.
In molecular biology, substrate presentation is a biological process that activates a protein. The protein is sequestered away from its substrate and then activated by release and exposure to its substrate. [1] [2] A substrate is typically the substance on which an enzyme acts but can also be a protein surface to which a ligand binds. In the ...
Substrate (biology), the natural environment in which an organism lives, or the surface or medium on which an organism grows or is attached Substrate (aquatic environment), the earthy material that exists in the bottom of an aquatic habitat, like dirt, rocks, sand, or gravel
When a substrate binds to one enzymatic subunit, the rest of the subunits are stimulated and become active. Ligands can either have positive cooperativity, negative cooperativity, or non-cooperativity. The sigmoidal shape of hemoglobin's oxygen-dissociation curve results from cooperative binding of oxygen to hemoglobin.
Glucose binds to hexokinase in the active site at the beginning of glycolysis. In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. [1]
The catalysis of the peptide cleavage can be seen as a ping-pong catalysis, in which a substrate binds (in this case, the polypeptide being cleaved), a product is released (the C-terminus "half" of the peptide with amino group visible), another substrate binds (in this case, water), and another product is released (the N-terminus "half" of the ...
[1] [4] Iron ABC uptake systems, for example, are important effectors of virulence. [11] Pathogens use siderophores , such as Enterobactin , to scavenge iron that is in complex with high-affinity iron-binding proteins or erythrocytes .
An example of a substrate analog that is also a suicide substrate/Trojan horse substrate is penicillin, which is an inhibitory substrate analog of peptidoglycan. [8] Some substrate analogs can still allow the enzyme to synthesize a product despite the enzyme’s inability to metabolize the substrate analog.