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Stilbestrol, or stilboestrol, also known as 4,4'-dihydroxystilbene or 4,4'-stilbenediol, is a stilbenoid nonsteroidal estrogen [1] and the parent compound of a group of more potent nonsteroidal estrogen derivatives that includes, most notably, diethylstilbestrol (DES).
Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...
While the results are encouraging, the study did not evaluate VivaGel's effect in the body. It is still unknown what the results mean for women who would use the product in real-life settings; for example, the effect of sexual intercourse (or semen) on the gel (which often affects the protective properties of a drug) is unknown.
The WHO recommends avoiding ACT for women in their first trimester of pregnancy due to a lack of research on artemisinin's safety in early pregnancy. Instead the WHO recommends a seven-day course of clindamycin and quinine. [15] For pregnant women in their second or third trimesters, the WHO recommends a normal treatment course with an ACT. [16]
Common name o-cresol: m-cresol: p-cresol: Preferred IUPAC name: 2-methylphenol 3-methylphenol 4-methylphenol Systematic name: 2-methylbenzenol 3-methylbenzenol 4-methylbenzenol Other names ortho-cresol 2-hydroxytoluene meta-cresol 3-hydroxytoluene para-cresol 4-hydroxytoluene Molecular formula: C 7 H 8 O SMILES: oc1c(C)cccc1 oc1cc(C)ccc1 oc1ccc ...
Stigmasterol is a food additive in manufactured food products in the United Kingdom and European Union. [7]It was introduced as a precursor by Percy Lavon Julian for industrial large-scale manufacture of semisynthetic progesterone, [8] [9] [10] a valuable human hormone that plays an important physiological role in the regulatory and tissue rebuilding mechanisms related to estrogen effects, as ...
Catechol (/ ˈ k æ t ɪ tʃ ɒ l / or / ˈ k æ t ɪ k ɒ l /), also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C 6 H 4 (OH) 2.It is the ortho isomer of the three isomeric benzenediols.
The first-in-human study, a phase 1 trial, was initiated in October 2017 and completed in September 2020 in postmenopausal women with breast cancer. [ 10 ] [ 3 ] [ 2 ] [ 17 ] [ 15 ] The study investigated oral doses of vosilasarm of 50 mg/day to 150 mg/day, with the maximum tolerated dose found to be 100 mg/day.