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  2. DNA and RNA codon tables - Wikipedia

    en.wikipedia.org/wiki/DNA_and_RNA_codon_tables

    [2] [3] The mRNA sequence is determined by the sequence of genomic DNA. [4] In this context, the standard genetic code is referred to as 'translation table 1' among other tables. [3] It can also be represented in a DNA codon table. The DNA codons in such tables occur on the sense DNA strand and are arranged in a 5 ′-to-3 ′ direction.

  3. Genetic code - Wikipedia

    en.wikipedia.org/wiki/Genetic_code

    The most common start codon is AUG, which is read as methionine or as formylmethionine (in bacteria, mitochondria, and plastids). Alternative start codons depending on the organism include "GUG" or "UUG"; these codons normally represent valine and leucine, respectively, but as start codons they are translated as methionine or formylmethionine. [33]

  4. Start codon - Wikipedia

    en.wikipedia.org/wiki/Start_codon

    Alternative start codons are different from the standard AUG codon and are found in both prokaryotes (bacteria and archaea) and eukaryotes. Alternate start codons are still translated as Met when they are at the start of a protein (even if the codon encodes a different amino acid otherwise). This is because a separate tRNA is used for ...

  5. N6-Methyladenosine - Wikipedia

    en.wikipedia.org/wiki/N6-Methyladenosine

    Following a 2010 speculation of m 6 A in mRNA being dynamic and reversible, [27] the discovery of the first m 6 A demethylase, fat mass and obesity-associated protein in 2011 [28] confirmed this hypothesis and revitalized the interests in the study of m 6 A. A second m 6 A demethylase alkB homolog 5 (ALKBH5) was later discovered as well. [29]

  6. Methionine - Wikipedia

    en.wikipedia.org/wiki/Methionine

    Methionine ball and stick model spinning. Methionine (symbol Met or M) [3] (/ m ɪ ˈ θ aɪ ə n iː n /) [4] is an essential amino acid in humans.. As the precursor of other non-essential amino acids such as cysteine and taurine, versatile compounds such as SAM-e, and the important antioxidant glutathione, methionine plays a critical role in the metabolism and health of many species ...

  7. Vertebrate mitochondrial code - Wikipedia

    en.wikipedia.org/wiki/Vertebrate_mitochondrial_code

    However, at least in humans it has now been shown that AGA and AGG sequences are not recognized as termination codons. A -1 mitoribosome frameshift occurs at the AGA and AGG codons predicted to terminate the CO1 and ND6 open reading frames (ORFs), and consequently both ORFs terminate in the standard UAG codon.

  8. Kozak consensus sequence - Wikipedia

    en.wikipedia.org/wiki/Kozak_consensus_sequence

    The AUG is the initiation codon encoding a methionine amino acid at the N-terminus of the protein. (Rarely, GUG is used as an initiation codon, but methionine is still the first amino acid as it is the met-tRNA in the initiation complex that binds to the mRNA). Variation within the Kozak sequence alters the "strength" thereof.

  9. Translation (biology) - Wikipedia

    en.wikipedia.org/wiki/Translation_(biology)

    Overview of eukaryotic messenger RNA (mRNA) translation Translation of mRNA and ribosomal protein synthesis Initiation and elongation stages of translation involving RNA nucleobases, the ribosome, transfer RNA, and amino acids The three phases of translation: (1) in initiation, the small ribosomal subunit binds to the RNA strand and the initiator tRNA–amino acid complex binds to the start ...