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In molecular biology, alpha-amylase inhibitor (or α-...) is a protein family which inhibits mammalian alpha-amylases specifically, by forming a tight stoichiometric 1:1 complex with alpha-amylase. This family of inhibitors has no action on plant and microbial alpha amylases. They are found in raw plants/herbs such as cinnamon and bacteria ...
Diabetes: α-glucosidase and alpha-amylase inhibitors are found in several raw plants/herbs such as cinnamon [18] and bacteria containing acarbose [19] They are used as anti-diabetic drugs. The intake of a single dose of before a meal containing complex carbohydrates clearly suppresses the glucose spike and may decrease the postprandial ...
As of 2017, an estimated 29% of approved drugs are enzyme inhibitors [96] of which approximately one-fifth are kinase inhibitors. [96] A notable class of kinase drug targets is the receptor tyrosine kinases which are essential enzymes that regulate cell growth; their over-activation may result in cancer.
Human enzymes do transform acarbose: the pancreatic alpha-amylase is able to perform a rearrangement reaction, moving the glucose unit in the "tail" maltose to the "head" of the molecule. Analog drugs with the "tail" glucose removed or flipped to an α(1-6) linkage resist this transformation. [14]
Alpha-glucosidase inhibitors (AGIs) are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar). They are found in raw plants/herbs such as cinnamon and bacteria (containing the inhibitor acarbose ).
Beans also contain alpha amylase inhibitor, but not in sufficient quantities to affect the digestion of starch after consumption of beans. [9] Poisoning can be induced from as few as four raw beans. Symptoms usually begin with extreme nausea and vomiting within one to three hours of ingestion, followed by diarrhea.
Taliglucerase alfa, sold under the brand name Elelyso among others, is a biopharmaceutical medication developed by Protalix and Pfizer. [3] [4] [full citation needed] The drug, a recombinant glucocerebrosidase used to treat Gaucher's disease, is the first plant-made pharmaceutical to win approval by the U.S. Food and Drug Administration (FDA).
279 11722 Ensembl ENSG00000243480 ENSMUSG00000074264 UniProt P04746 P00687 RefSeq (mRNA) NM_000699 NM_001110505 NM_007446 RefSeq (protein) NP_000690 NP_001103975 NP_031472 Location (UCSC) Chr 1: 103.62 – 103.63 Mb Chr 3: 113.35 – 113.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Pancreatic alpha-amylase is an enzyme that in humans is encoded by the AMY2A gene. Amylases are ...