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Eosinophilia–myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion of the dietary supplement L-tryptophan. [1] [2] The risk of developing EMS increases with larger doses of tryptophan and increasing age. [3] Some research suggests that certain genetic polymorphisms may be related to the development of EMS. [4]
Sir Jack Martin Cuzick [2] (born 11 August 1948) is an American-born British academic, director of the Wolfson Institute of Preventive Medicine in London and head of the Centre for Cancer Prevention. He is the John Snow Professor of Epidemiology at the Wolfson Institute, Queen Mary University of London .
Tryptophan ball and stick model spinning. Tryptophan (symbol Trp or W) [3] is an α-amino acid that is used in the biosynthesis of proteins.Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent.
Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase , phenylalanine hydroxylase , and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases .
121278 216343 Ensembl ENSG00000139287 ENSMUSG00000006764 UniProt Q8IWU9 Q8CGV2 RefSeq (mRNA) NM_173353 NM_173391 RefSeq (protein) NP_775489 NP_775567 Location (UCSC) Chr 12: 71.94 – 72.19 Mb Chr 10: 114.91 – 115.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is ...
1-Methyltryptophan is a chemical compound that is an inhibitor of the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase (IDO or INDO EC 1.13.11.52). [1] It is a chiral compound that can exist as both D - and L-enantiomers. The L-isomer (L-1MT) inhibits IDO weakly but also serves as an enzyme substrate.
[8]: 327–328 Multiple epidemiological studies [7] [9] [10] traced an outbreak of eosinophilia-myalgia syndrome (EMS) to L-tryptophan supplied by Showa Denko, which resulted in 37 deaths. [11] [12] It was further hypothesized that one or more trace impurities produced during the manufacture of tryptophan may have been responsible for the EMS ...
Tryptophan 2,3-dioxygenase is a heme-containing cytosolic enzyme encoded by gene TDO2. [5] Crystallographic studies of Xanthomonas campestris TD) [13] and Ralstonia metallidurans TDO) [16] have revealed that their structures are essentially identical and are intimately associated homotetrameric enzymes. [17]