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Effects on weight were seen primarily in people who took berberine in doses of more than 1 gram per day and for more than 8 weeks. Many of the studies included in this review had a high risk of bias, and the outcomes of individual studies were inconsistent.
In preclinical models, Berberine demonstrates that it affects gut microbiota by reducing diversity of microbes starting at a dosage of 100 mg/kg/day. Moreover, in animal models, Berberine explicates an action on glucose through the inhibition of α-glycosidase at a dose of 200 mh/kg/day.
Berberine alone in patients with metabolic disorders can play a good therapeutic effect containing blood lipid-lowering, blood sugar-lowering, and insulin resistance amelioration, and the therapeutic effect becomes conspicuous with treatment time > 3 months.
It has been shown to improve blood sugar control, lower cholesterol, inhibit infectious microorganisms, decrease inflammation, ameliorate inflammatory bowel disease, lower blood pressure, facilitate weight loss, and even inhibit cancer cells.
Various animal and culture models have reported on the ability of berberine to exert lipid and glucose-lowering effects in addition to helping with weight loss and improving glucose tolerance [2,3]. For this reason, interest in berberine has suggested it may be beneficial in treating diabetes and obesity.
Today, berberine is often sold as an herbal dietary supplement and is promoted as a remedy for diabetes, high cholesterol levels, high blood pressure, and canker sores, and most recently as a weight loss aid.
This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake which may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders.