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For example, if the primary tumor grade was 2 and the secondary tumor grade was 3 but some cells were found to be grade 4, the Gleason score would be 2+4=6. This is a slight change from the pre-2005 Gleason system where the second number was the secondary grade (i.e., the grade of the second-most common cell line pattern).
In the United States during 2013–2017, the age-adjusted mortality rate for all types of cancer was 189.5/100,000 for males, and 135.7/100,000 for females. [1] Below is an incomplete list of age-adjusted mortality rates for different types of cancer in the United States from the Surveillance, Epidemiology, and End Results program.
Prostate cancer is the most diagnosed cancer in men in over half of the world's countries, and the leading cause of cancer death in men in around a quarter of countries. [91] Prostate cancer is rare in those under 40 years old, [92] and most cases occur in those over 60 years, [2] with the average person diagnosed at 67. [93]
In fact, the five-year survival rate after a prostate cancer diagnosis is 97%. ... Risk factors for prostate cancer include certain ethnicities, age and, in some cases, inherited genetic factors. ...
Lowering the recommended age for baseline PSA testing in Black men could reduce prostate cancer deaths by about 30% without significantly increasing overdiagnosis rates, according to recent findings.
age: age at diagnosis; eet: early endocrine therapy (1=no, 0=yes) ploidy: diploid/tetraploid/aneuploid DNA pattern; g2: % of cells in G2 phase; grade: tumor grade (1-4) gleason: Gleason grade (3-10) The survival tree produced by the analysis is shown in the figure. Survival tree for prostate cancer data set
In fact, the five-year survival rate for prostate cancer detected early is virtually 100%, Siddiqui says. The outlook for late-diagnosed patients, however, is not nearly as rosy.
The rate of death from prostate cancer at 10 years for men age 65–74 years with moderately differentiated cancers (Gleason score 5–7) diagnosed with screening (in the prostate cancer screening era) and pre prostate cancer screening eras (without screening) were from 2-6%, and from 15 to 23%, respectively.
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