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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
Therefore, they are effective in Type 2 diabetics; and in Type 1 diabetes when used in conjunction with insulin therapy. [ citation needed ] Mainly used in Type II diabetes, metformin is considered to increase insulin sensitivity in vivo, resulting in reduced plasma glucose concentrations, increased glucose uptake, and decreased gluconeogenesis.
1,4-Dimethylamylamine (1,4-DMAA), also known as 1,4-dimethylpentylamine or as 5-methylhexan-2-amine, is a stimulant drug of the alkylamine family related to methylhexanamine (1,3-DMAA; geranamine). [ 1 ] [ 2 ] It is naturally present in geranium plants and has also been found in certain other plants.
[4] [5] Antipsychotics like quetiapine and olanzapine and antidepressants like trazodone and mirtazapine are all potent serotonin 5-HT 2A receptor antagonists. [ 6 ] [ 28 ] [ 29 ] Conversely, benzodiazepines and alcohol act as positive allosteric modulators of the GABA A receptor and have anxiolytic and sedative effects. [ 30 ]
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It acts as a monoamine releaser with selectivity for serotonin and has a similar potency to MDMA. [1] [2] [5] [3] [6] In terms of monoamine release, (S)-βk-5-MAPB has shown a DAT Tooltip dopamine transporter /SERT Tooltip serotonin transporter ratio of 0.6 and a DAT/NET Tooltip norepinephrine transporter ratio of 2.7, while (R)-βk-5-MAPB has shown a DAT/SERT ratio of 18 and a DAT/NET ratio ...
meta-Chlorophenylbiguanide (1-(3-Chlorophenylbiguanide, m-CPBG) is an allosteric agonist and modulator of the 5-HT 3 receptor [1] [2] [3] and an antagonist of the α 2A-adrenergic receptor. [4] It has anxiogenic , emetic and hypothermic effects in animal studies.
1-(2-Dimethylaminoethyl)dihydropyrano(3,2-e)indole (4,5-DHP-DMT) is a tricyclic tryptamine derivative which acts as a potent and reasonably selective partial agonist for the serotonin receptor 5-HT 2A, with a K i of 17.0 nM, and moderate selectivity over related serotonin receptors.