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Ensulizole (INN; [1] also known as phenylbenzimidazole sulfonic acid) is a common sunscreen agent. In 1999, the United States Food and Drug Administration regulated that the name ensulizole be used on sunscreen labels in the United States.
2-Aminophenol is an organic compound with the formula C 6 H 7 NO. Along with its isomer 4-aminophenol , it is an amphoteric molecule and a reducing agent . It is a useful reagent for the synthesis of dyes and heterocyclic compounds . [ 3 ]
2-Aminothiophenol is an organosulfur compound with the formula C 6 H 4 (SH)(NH 2). It is a colorless oily solid, although impure samples can be deeply colored. It is soluble in organic solvents and in basic water. 2-Aminothiophenol is a precursor to benzothiazoles, some of which are bioactive or are commercial dyes.
Benzimidazole is a base: C 6 H 4 N(NH)CH + H + → [C 6 H 4 (NH) 2 CH] + It can also be deprotonated with stronger bases: C 6 H 4 N(NH)CH + LiH → Li [C 6 H 4 N 2 CH] + H 2. The imine can be alkylated and also serves as a ligand in coordination chemistry. The most prominent benzimidazole complex features N-ribosyl-dimethylbenzimidazole, as ...
5,6-Dimethylbenzimidazole is a natural benzimidazole derivative. It is a component of vitamin B 12 where it serves as a ligand for the cobalt atom. [1] 5,6-Dimethylbenzimidazole is biosynthesized from flavin mononucleotide by the enzyme 5,6-dimethylbenzimidazole synthase. [2]
Structures with names 4- and 5-nitroimidazole are equivalent from the perspective of drugs since these tautomers readily interconvert. Drugs of the 5-nitro variety include metronidazole, tinidazole, nimorazole, dimetridazole, pretomanid, ornidazole, megazol, and azanidazole. Drugs based on 2-nitroimidazoles include benznidazole and azomycin. [3]
The structure-activity relationship of the drug class has been explored to a reasonable extent. The optimal substitution pattern is fairly tightly defined (i.e. N,N-diethyl on the amine nitrogen, 4-ethoxy on the benzyl ring and 5-nitro on the benzimidazole ring), but even derivatives incorporating only some of these features are still potent opioids.
2-Aminobiphenyl (2-ABP) is an organic compound with the formula C 6 H 5 C 6 H 4 NH 2. It is an amine derivative of biphenyl. It is a colorless solid, although aged samples can appear colored even black. [1] Palladacycles obtained from 2-aminobiphenyl are popular catalysts for cross-coupling. [2] It is prepared by hydrogenation of 2 ...